TABLE 2.
The application of silk fibroin as drug carrier.
| Delivery system | Loaded drug | Other excipients | Application | Subject | References |
|---|---|---|---|---|---|
| Porous scaffolds | − | TiO2 | Tissue engineering | Mice and NIH 3T3 cells | Kim et al. (2014) |
| Discs | Griffithsin | − | HIV | Rhesus macaques | Crakes et al. (2020) |
| Films | Inactivated polio vaccine (IPV) | − | Vaccine | Wistar rats | Stinson et al. (2020) |
| Porous scaffolds | Irisin | Calcium silicate, sodium alginate | Bone regeneration | Bone marrow stem cells and SD rats | Xin et al. (2019) |
| Hydrogels | Betamethasone | Tyramine-gellan gum | Rheumatoid arthritis | New Zealand white rabbits and chondrogenic primary cells | Oliveira et al. (2020) |
| Porous scaffolds | − | Sodium alginate, polyvinyl alcohol, magnesium hydroxide | Antibiosis | Hu02 cells | Eivazzadeh-Keihan et al. (2020) |
| Hydrogels | Dexamethasone sodium phosphate | Chitosan | − | L929 fibroblast cells | Akrami-Hasan-Kohal et al. (2021) |
| Porous scaffolds | Quercetin | Hydroxyapatite | Osteogenesis | Bone marrow-derived mesenchymal stem cells and SD rats | Song et al. (2018) |
| liposome | Basic fibroblast growth factor | Liposome | Deep second-degree scald | Mice and NIH/3T3 fibroblast cells | Xu et al. (2017) |
| Nanoparticle | Celecoxib or curcumin | − | Osteoarthritis | Human articular chondrocytes | Crivelli et al. (2019) |
| Films | − | Poly ethylene glycol (PEG) | Limbal stem cell deficiency (LSCD) | Limbal epithelial stem cells and rabbits | Li et al. (2017) |
| Porous scaffolds | Dental pulp stem cells | Hydroxyapatite | Dental pulp regeneration | Nude mice | Zhang et al. (2019) |
| Liposome | Doxorubicin | Liposome | Cancer | MCF-7 cells, MDA-MB231 cells and L929 fibroblasts | Suyamud et al. (2021) |
| Scaffolds | Stromal cell derived factor-1 (SDF-1) and bone morphogenetic protein-2 | Nano-hydroxyapatite | Bone regeneration | Bone marrow mesenchymal stem cells | Shen et al. (2016) |
| Films | An antimicrobial peptide (Cys-KR12) | − | Wound healing | Monocytes (Raw264.7) | Song et al. (2016) |
| Hydrogels | − | Bioink, graphene oxide | Tissue engineering | − | Kim et al. (2021) |
| Microneedle | Composite insulin | - | Diabetes | Mice | Zhu et al. (2020) |
| Microneedle | Melatonin | Proline, melatonin | Insomnia | Rats | Qi et al. (2021) |
| Scaffolds | − | Gelatin | Bone tissue engineering | Rats and mesenchymal stem cell | Luetchford et al. (2020) |
| Microcapsules | Plasmid DNA | − | − | NIH 3T3 cell and mice | Li et al. (2014) |
| Scaffolds | Usnic acid | − | Wound healing | Mice | Zha et al. (2021) |
| Nanofiber | Cationic peptide | Chitosan | Wound healing | Hu02 human foreskin fibroblast cells | Khosravimelal et al. (2021) |
| Discs | Curcumin | Poly(lactic acid) | Cancer | human cervical cancer cells | Patwa et al. (2018) |