Table 3.
Heterogeneity and pleiotropy analysis of IBD, UC, and CD with CeD using different analytical methods.
| Exposure traits | MR methods | CeD | ||||
|---|---|---|---|---|---|---|
| Cochran Q statistic | Heterogeneity p-value | Pleiotropy p-value | MR-PRESSO global outlier test | |||
| RSSOBs | p-value | |||||
| IBD | IVW | 27.5626 | 0.1201 | 0.5212 | 30.9557 | 0.125 |
| UC | IVW | 15.8174 | 0.1997 | 0.3715 | 18.3589 | 0.212 |
| CD | IVW | 32.4019 | 0.0035 | 0.9157 | 36.8474 | 0.01 |
MR, Mendelian Randomization; CeD, Celiac Disease; UC, Ulcerative Colitis; MR-PRESSO, MR pleiotropy residual sum and outlier CD, Crohn’s Disease; IBD, Inflammatory Bowel Disease; IVW, Inverse variance weighted.