Fig. 2.

Schematic of the endocannabinoid system. The main endocannabinoids AEA and 2-AG are synthesized after postsynaptic cell stimulation. 2-AG is degraded by monoacylglycerol lipase (MAGL) which is expressed in the presynaptic terminal. While fatty acid amide hydrolase (FAAH) is localized to postsynaptic cells, which predominantly degrades AEA. AEA and 2-AG are transported across the membrane and respectively act on cannabinoid receptors (CB1 and CB2) which are expressed on presynaptic terminals, to exhibit the corresponding therapeutic effects.