Table 3.

Annual age-standardized incidence rate of hepatocellular carcinoma by age

Age	2008	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	AAPC	95% CI	P-value
Total (per 100,000 person-years)
All	21.9	20.5	19.3	19.0	17.8	17.2	16.7	16.1	15.9	15.1	14.3	-3.90	-4.20 to -3.50	<0.001
Men	33.7	31.4	29.6	29.0	27.5	26.4	25.5	24.6	24.0	22.7	21.6	-4.20	-4.70 to -3.70	<0.001
Women	9.6	9.1	8.5	8.4	7.6	7.3	7.1	7.0	7.0	6.7	6.2	-3.90	-5.00 to -2.90	<0.001
0–29 years (per 100,000 person-years)
All	0.4	0.3	0.2	0.2	0.1	0.1	0.1	0.1	0.1	0.1	0.1	-13.59	-16.48 to -10.60	<0.001
Men	0.5	0.3	0.3	0.2	0.2	0.1	0.1	0.1	0.1	0.1	0.1	-14.10	-19.70 to -8.10	<0.001
Women	0.2	0.2	0.2	0.2	0.0	0.1	0.1	0.0	0.0	0.1	0.1	-44.60	-88.80 to 166.20	0.400
30–59 years (per 100,000 person-years)
All	25.8	25.7	25.1	25.6	24.2	23.8	23.1	22.5	21.9	20.6	19.2	-3.10	-4.10 to -2.10	<0.001
Men	42.9	43.0	42.1	42.8	40.8	40.4	39.2	37.6	36.9	34.3	32.2	-2.80	-3.60 to -2.10	<0.001
Women	8.0	7.7	7.4	7.7	7.0	6.7	6.6	7.0	6.4	6.4	5.7	-2.80	-3.60 to -2.10	<0.001
60–79 years (per 100,000 person-years)
All	97.5	92.8	90.5	92.2	92.9	91.2	93.1	94.7	99.5	98.4	98.5	0.20	-0.90 to 1.30	0.708
Men	163.6	154.0	150.7	154.3	158.8	156.1	159.6	163.8	171.1	172.0	173.0	0.70	-0.20 to 1.60	0.129
Women	46.3	45.3	43.9	44.0	41.7	40.9	41.6	41.1	43.9	41.4	40.9	-1.00	-1.70 to -0.40	0.007
≥80 years (per 100,000 person-years)
All	70.0	70.6	80.4	86.3	89.4	99.3	110.4	123.3	134.4	149.5	160.2	9.00	7.90 to 10.2	<0.001
Men	137.3	131.9	149.0	163.5	174.3	187.9	213.6	248.4	255.6	279.6	318.0	9.40	8.42 to 10.45	<0.001
Women	41.5	44.6	51.3	53.6	53.4	61.8	66.6	70.2	83.1	94.4	93.4	8.80	7.70 to 9.90	<0.001

AAPC, average annual percent change; CI, confidence interval.