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. 2022 Jul 4;29(1):33–50. doi: 10.3350/cmh.2022.0058

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Copyright © 2023 by The Korean Association for the Study of the Liver

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Manipulating Wnt signaling. Illustration of components and processes of Wnt signal transduction as druggable targets for liver cancer treatment. See the text for detail. Created with BioRender.com. GPC3, glypican-3; LRP, lipoprotein receptor-related protein; FZD, frizzed; DKK1, Dickkopf 1; ROR, receptor tyrosine kinase-like orphan receptor; RYK, receptor tyrosine kinase; PORCN, porcupine; ER, endoplasmic reticulum; GSK-3β, glycogen synthase kinase 3β; CK1α, casein kinase 1α; APC, adenomatous polyposis coli; TCF, T-cell factor; CBP, CREB binding protein; LEF, lymphoid enhancer-binding factor; peg-IFN, pegylated-Interferon-α2a; RanBP3, Ran-binding protein 3.