Table 1.
Targeting Wnt signaling in liver cancers
| Agent | Target | Phase | Trial identifier | Type |
|---|---|---|---|---|
| DKN-01 | DKK1 | Phase I/II | NCT03645980 | Protein |
| OMP-18R5 | FZD1, 2, 5, 7, and 8 | Phase I | NCT01345201 | Protein |
| sFZD7 | FZD7 | Preclinical | NA | Protein |
| RHPDs | FZD7 | Preclinical | NA | Protein |
| OMP-54F28 | FZD8 | Phase I | NCT02069145 | Protein |
| Salinomycin | LRP5/6 | Preclinical | NA | Natural compounds |
| CGX1321 | PORCN | Phase I | NCT03507998 | Small molecule inhibitors |
| IWP12 | PORCN | Preclinical | NA | Small molecule inhibitors |
| ETC-159 | PORCN | Phase I | NCT02521844 | Small molecule inhibitors |
| RXC004 | PORCN | Phase I | NCT03447470 | Small molecule inhibitors |
| NVP-TNKS656 | Tankyrase | Preclinical | NA | Small molecule inhibitors |
| XAV939/WXL-8 | Tankyrase | Preclinical | NA | Small molecule inhibitors |
| CGP049090 | TCF/β-catenin | Preclinical | NA | Natural compounds |
| PKF118-310 | TCF/β-catenin | Preclinical | NA | Natural compounds |
| PKF115-584 | TCF/β-catenin | Preclinical | NA | Natural compounds |
| FH535 | TCF/β-catenin | Preclinical | NA | Small molecule inhibitors |
| Peg-IFN | TCF/β-catenin | Phase II | NCT00610389 | Protein |
| WIF1-Fc and sFRP-Fc | Wnt ligands | Preclinical | NA | Protein |
| Anti-Wnt1 | Wnt1 | Preclinical | NA | Protein |
| CGK062 | β-catenin phosphorylation | Preclinical | NA | Small molecule inhibitors |
| PMED-1 | β-catenin/CBP | Preclinical | NA | Small molecule inhibitors |
| PRI-724 | β-catenin/CBP | Phase I/II | NCT01302405 | Small molecule inhibitors |
| Hydroxychloroquine | v-ATPase | Phase II | NCT03037437 | Small molecule inhibitors |
| Chloroquine | v-ATPase | Preclinical | NA | Small molecule inhibitors |
| Bafilomycin | v-ATPase | Preclinical | NA | Small molecule inhibitors |
| Concanamycin | v-ATPase | Preclinical | NA | Small molecule inhibitors |
| CAR-GPC3 T cell | GPC3 | Phase I | NCT02932956 | Cells |
| Anti-GPC3 antibody | GPC3 | Phase II | NCT01507168 | Protein |
| CIK with anti-GPC3 | GPC3 | Phase II | NCT03146637 | Cells |
DKK1, Dickkopf 1; FZD, frizzed; NA, not available; PORCN, porcupine; TCF, T-cell factor; peg-IFN, pegylated-Interferon-α2a; CBP, CREB binding protein; v-ATPase, vacuolar-type ATPase.