Figure 4.

Decision curve analysis demonstrating the benefit of initiating non-selective beta-blocker based on various strategies such as treating “high-risk varices” (pink), “all esophageal varices” (red), “treat definite CSPH” (green), “treat probable CSPH” (turquoise) and “treat none” (brown), across different threshold risk of annual decompensation. The area under the curve between different lines and the brown line (treat none) reflect the estimated benefit of each treatment strategy. At a treatment threshold between 5–10% of decompensation rate, treating “definite CSPH” is the best strategy to initiate non-selective beta-blocker to prevent decompensation. CSPH, clinically significant portal hypertension.