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. 2023 Jan 4;13:1001264. doi: 10.3389/fimmu.2022.1001264

Figure 2.

Figure 2

Histopathology of appendiceal goblet cell carcinoma of the patient. Tumor cells exhibit a goblet cell morphology and characteristically form small tight clusters (A). The immunohistochemical staining shows moderate positivity for CK20 (B), CDX-2 (C), and strong positivity for carcinoembryonic antigen (CEA, D). Staining for synaptophysin (Syn, E), and chromogranin (F) is mild. Varying degrees of positivity are also shown in lymphocytes such as CD3+ T cells (G), CD8+ T cells (H) and CD20+ B cells (I). Immunohistochemistry shows positive staining for amphiphysin-IgG (J). Tissue-based indirect immunofluorescence assay (TBA) of the patient’s serum detected fluorescence responses, with specific fluorescence responses in Purkinje cells (red arrows) from the monkey cerebellum brain section (K) as well as dentate gyrus glial cells (white arrows) from the monkey hippocampal tissue. (A,–C, G, J) bar = 50 µm; D, H bar = 250 µm; (E, F, O) bar = 100 µm, (K, L) bar = 20 µm).