Table 4.
Univariable and multivariable Cox regression analyses for RFS of pCCA patients.
| Variables | Comparison | Univariable analyses | Multivariable analyses* | ||
|---|---|---|---|---|---|
| P value | HR (95% CI) | P value | HR (95% CI) | ||
| Age | > 60 vs. ≤ 60 years | 0.115 | 1.011 (0.997-1.021) | ||
| Gender | Male vs. Female | 0.353 | 0.889 (0.692-1.139) | ||
| ASA score | > 2 vs. ≤ 2 | 0.996 | 1.001 (0.779-1.281) | ||
| Comorbidity | Yes vs. No | 0.295 | 1.158 (0.878-1.541) | ||
| Preoperative jaundice | Yes vs. No | 0.199 | 1.982 (0.911-1.582) | ||
| ALB | < 35 vs. ≥ 35 g/L | 0.138 | 0.823 (0.641-1.072) | ||
| ALT | > 40 vs. ≤ 40 U/L | 0.077 | 1.326 (0.971-1.836) | ||
| AST | > 40 vs. ≤ 40 U/L | 0.350 | 1.162 (0.851-1.592) | ||
| NLR* | < 1.68 vs. ≥ 1.68 | <0.001 | 1.938 (1.511-2.479) | <0.001 | 1.598 (1.224-2.088) |
| PLR* | < 113.1 vs. ≥ 113.1 | <0.001 | 2.772 (2.121-3.623) | <0.001 | 2.138 (1.613-2.833) |
| CA 19-9* | > 150 vs. ≤ 150 U/L | 0.006 | 1.516 (1.132-2.047) | 0.227 | 1.210 (0.888-1.649) |
| INR | > 1.25 vs. ≤ 1.25 | 0.503 | 1.192 (0.711-1.992) | ||
| Cirrhosis | Yes vs. No | 0.836 | 1.050 (0.671-1.639) | ||
| Chronic hepatitis | Yes vs. No | 0.375 | 0.822 (0.521-1.280) | ||
| Hepatolithiasis | Yes vs. No | 0.269 | 1.286 (0.821-2.005) | ||
| Maximum tumor size* | < 3 cm vs. ≥ 3 cm | 0.002 | 1.491 (1.162-1.912) | 0.011 | 1.398 (1.080-1.812) |
| Tumor differentiation* | poor vs. well/moderate | <0.001 | 1.931 (1.403-2.659) | 0.099 | 1.411 (0.937-2.124) |
| Macrovascular invasion* | Yes vs. No | 0.001 | 1.592 (1.221-2.093) | 0.031 | 1.367 (1.030-1.815) |
| Microvascular invasion* | Yes vs. No | <0.001 | 2.179 (1.531-3.108) | 0.239 | 1.313 (0.835-2.065) |
| Peripheral nerve invasion | Yes vs. No | 0.637 | 1.071 (0.822-1.389) | ||
| lymph node metastasis* | Yes vs. No | <0.001 | 2.047 (1.593-2.629) | <0.001 | 1.638 (1.246-2.154) |
| Extent of hepatectomy | Major vs. Minor | 0.784 | 1.039 (0.791-1.364) | ||
*Those variables found significant at P <.100 in univariable analyses were entered into multivariable Cox regression analyses.
ALB, albumin level; ALT, alanine aminotransferase; ASA, American Society of Anesthesiologists; AST, aspartate transaminase; CA19-9, carbohydrate antigen 19-9; CI, confidence interval; HR, hazard ratio; INR, international normalized ratio; NLR, neutrophil-to-lymphocyte ratio; pCCA, perihilar cholangiocarcinoma; PLR, platelet-to-lymphocyte ratio; PLT, platelet level; RFS, recurrence-free survival; TB, total bilirubin.