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. 2023 Jan 4;13:972878. doi: 10.3389/fphar.2022.972878

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Copyright © 2023 Wang, Zhang, Hu, He, Zhu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model prediction. (A) Actual maximal efficacy (AE_max) of dapagliflozin on HbA1c; (B) after it reached the AE_max, the dapagliflozin therapeutic effect on HbA1c continuing the treatment for 0.5 years (26 weeks), at week 35; and (C) after it reached the AE_max, the dapagliflozin therapeutic effect on HbA1c continuing the treatment for 1 year (52 weeks) at week 61.