Table 6.
Multivariate analysis of hazards ratios for OS and DFS by MetS components.
| Variable | OS | DFS | ||||
|---|---|---|---|---|---|---|
| HR | CI (95%) | P | HR | CI (95%) | P | |
| MetS status | ||||||
| No | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
| Yes | 2.587 | 1.359-4.924 | 0.004 | 2.228 | 1.251-3.970 | 0.007 |
| BMI (kg/m2) | ||||||
| <25 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
| ≥25 | 1.548 | 0.852-2.813 | 0.151 | 1.609 | 0.961-2.693 | 0.071 |
| FBG (mmol/L) | ||||||
| <6.1 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
| ≥6.1 | 1.902 | 0.981-3.687 | 0.057 | 1.687 | 0.905-3.147 | 0.100 |
| TG (mmol/L) | ||||||
| <1.7 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
| ≥1.7 | 2.452 | 1.271-4.731 | 0.007 | 1.855 | 1.046-3.291 | 0.035 |
| HDL-C (mmol/L) | ||||||
| ≥1.3 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
| <1.3 | 2.069 | 1.073-3.988 | 0.030 | 1.883 | 1.066-3.327 | 0.029 |
| Hypertension | ||||||
| No | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
| Yes | 1.639 | 0.883-3.041 | 0.117 | 1.802 | 1.042-3.116 | 0.035 |
| Number of components | ||||||
| 0 components | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
| 1–2 components | 1.763 | 0.750-4.144 | 0.194 | 1.951 | 0.949-4.009 | 0.069 |
| 3 components | 2.865 | 1.036-7.922 | 0.042 | 2.995 | 1.250-7.176 | 0.014 |
| 4 components | 6.304 | 1.692-23.492 | 0.006 | 4.584 | 1.335-15.734 | 0.016 |
| 5 components | 15.488 | 3.282-73.083 | 0.001 | 12.129 | 2.833-51.921 | 0.001 |
OS, overall survival; DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; MetS, metabolic syndrome; BMI, body mass index; FBG, fasting blood glucose; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol.
Multivariate analysis adjusted for age, menopausal state, number of births, T Stage, N Stage, hormone receptors status, HER2 status, Ki67, p53 status, molecular subtype, endocrine therapy and radiation therapy.