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. 2023 Jan 4;13:1074044. doi: 10.3389/fimmu.2022.1074044

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Copyright © 2023 Nikoloudaki, Nikolopoulos, Koutsoviti, Flouri, Kapsala, Repa, Katsimbri, Theotikos, Pitsigavdaki, Pateromichelaki, Bertsias, Elezoglou, Sidiropoulos, Fanouriakis, Boumpas and Bertsias

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baseline factors may predict clinical response trajectories in belimumab-treated SLE patients. Multinomial regression analysis was performed to identify baseline clinical parameters associated with the trajectory-based groups of response to belimumab. Patients with baseline PGA ≥2.0 or inflammatory rash were more likely to belong to the partial response (PR) (odds ratio [OR] 2.74; 95% confidence interval [95% CI] 1.09–6.85 and OR 2.37; 95% CI 1.05–5.35, respectively) and the non-response (NR) (OR 3.19; 95% CI 1.27–8.06 and OR 4.07; 95% CI 1.70–9.71, respectively) than the complete response (CR) group. Leukopenia was linked to reduced risk for PR as compared to CR (OR 0.07; 95% CI 0.01–0.61) and NR (OR 0.07; 95% CI 0.01–0.56). Prior use of mycophenolate was associated with lower risk for PR versus NR (OR 0.25; 95% CI 0.09–0.71).