Figure 8.

Alteration of KEGG pathways at different stages of HIV infection. In the context of HIV infection, the “bacterial invasion of epithelial cells”, “phosphonate and phosphate metabolism”, and “tryptophan metabolism” and pathways were up-regulated in AIDS group, while the “vitamin B6 metabolism” pathways were down-regulated (FDR P<0.1). The “IL-17 signalling pathway”, “Th17 cell differentiation”, “nicotinate and nicotinamide metabolism”, “aminoacyl-tRNA biosynthesis”, and “phenylalanine, tyrosine and tryptophan biosynthesis” showed a downward trend with the severity of the disease (FDR P<0.1).