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. 2023 Jan 4;13:1068978. doi: 10.3389/fimmu.2022.1068978

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Copyright © 2023 Guan, Zhang, Zhang, Song and Zhong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical manifestations and histopathological features. (A) Erythematous patches and tense bullae on the patient’s trunk and extremities (CTCAE grade 3). (B) Numerous large tense bullae on the hand. (C) Histopathologic examination of a skin lesion on the right hand revealed a subepidermal blister cavity (H&E, 100×). (D) Eosinophils infiltrated the upper and mid-dermis (400×). Immunostaining revealed (E) a predominantly CD4⁺ (400×) lymphocytic infiltrate, with (F) a few CD8⁺ cells (400×) and the occasional CD20⁺ cell.