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. 2023 Jan 4;14:1025473. doi: 10.3389/fnagi.2022.1025473

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Copyright © 2023 Kabir, Atkinson, Cook, Phipps and King.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of acetylation and deacetylation on microtubule stability. Microtubules are constantly being modified through the addition and removal of acetylation by HATs and HDACs. Binding of Microtubule associated proteins or MAPs to microtubules is also regulated by acetylation and also affects their stability (Cohen et al., 2011). These modifications allow for the rapid expansion and removal of microtubule structures for neurite outgrowth, synapse formation, transport through the axon, and maintaining the overall structure of the axon.