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. 2023 Jan 4;10:1058846. doi: 10.3389/fcell.2022.1058846

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Copyright © 2023 Asal, Koçak, Sarı, Reçber, Nemutlu, Utine and Güven.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolomic analysis of cell and culture medium (A) PLS-DA score plot for metabolomic profiles of cell lines at different time points and presence of the stimulant (R ² = .820 and Q²: .978) (B) PLS-DA score plot for exometabolomic profiles of cell culture mediums (R ² = .410 and Q²: .117) (C) Heat map for cell metabolites (D) Heat map for cell culture medium metabolites (n = 6 biological replicates).