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. 2023 Jan 4;13:991604. doi: 10.3389/fimmu.2022.991604

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Copyright © 2023 Li, Jin, Chen, Zhang, Li, Zhong, Fan and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of cuproptosis induced by elesclomol. (A) Cell viability of HCC cell when grown in the presence or absence of serum and treated with elesclomol. (B) Cell viability of HCC cell when grown in the presence or absence of serum and treated with either elesclomol or elesclomol in the presence of CuCl2. (C, D) HA22T and Huh7 cells were exposed to different doses of elesclomol for 24h and detected by CCK8 reagent. (E, F) Representative images of HCC cells treated with elesclomol (40nM) with or without TTM (5 μM) for 48h. Scale bars represent 200μm. (G, H) The rescue effect of cell death inhibitors on elesclomol treatment in HA22T and Huh7 was explored through CCK8 assay. Data was presented as mean+SD. ZVF, Z-VAD-FMK; Fer-1, ferrostatin-1; Nec-1, necrostatin-1; NAC, N-acetyl cysteine; TTM, Tetrathiomolybdate.