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. 2023 Jan 4;16:1077071. doi: 10.3389/fncel.2022.1077071

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Copyright © 2023 Huang, Chen, He, Fu, Xu and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exosomal Integrin-β1 of SCs-Exos promotes new blood vessel formation after SCI. The presence of proliferation of blood vessels in the spinal cord on day seven after SCI was analyzed by immunofluorescence staining. (A) Representative image of CD31-positive (Red) and PCNA-positive (Green) cells in the anterior horn of the spinal cord from each group at 7 days post-injury. (B) Quantitative analysis of CD31/PCNA-positive cells in the injured spinal cords from each group. The data are presented as mean ± SD. **p < 0.01 Control group vs. SCs^ctrlshRNA-Exos group, ^##p < 0.01 SCs^ctrlshRNA-Exos group vs. SCs^{shIntegrin–β1}-Exos group. N = 5 in each group. Bar = 50 μm.