Table 2.

Linear mixed models examining the association between health-related profiles in brain aging and change in composite cognitive function and frailty index (FI).

	Unadjusted		Adjusted
	ab (95% CI)	p	ab (95% CI)	p
Resilient (n=159):
Composite cognitive function
Class R2 vs R1	0.03 (−0.002, 0.06)	0.07	0.04 (0.003, 0.07)	0.03*
FI
Class R2 vs R1	−0.001 (−0.01, 0.01)	0.84	−0.001 (−0.01, 0.004)	0.69
Advanced (n=167):
Composite cognitive function
Class R2 vs R1	0.01 (−0.04, 0.05)	0.78	0.01 (−0.04, 0.05)	0.84
FI
Class R2 vs R1	0.003 (−0.003, 0.01)	0.33	0.003 (−0.003, 0.01)	0.33

*p < 0.05. Models were adjusted for chronological age, sex and education. ^aUnstandardized beta-coefficient of the two-way interaction between class membership and time, which represents the difference in the rate of change in cognition and frailty between class 2 relative to class 1.