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. 2023 Jan 4;10:1079548. doi: 10.3389/fcell.2022.1079548

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Copyright © 2023 Liu, Lian, Shi, Hao and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of regulatory mechanisms of ferroptosis. Iron metabolic pathways, SystemX_c ⁻/glutathione axis, and lipid peroxidation engage in the regulation of ferroptosis. TFR1: transferrin receptor 1; FPN: ferroportin; DMT1: divalent metal transporter 1; STEAP3: six-transmembrane epithelial antigens of the prostate 3; NCOA4: Nuclear receptor coactivator 4; LIP: labile iron pool; ROS: reactive oxygen species; SLC3A2: Solute Carrier Family 3 Member 2; SLC7A11: Solute Carrier Family 7 Member 11; PUFAs: polyunsaturated fatty acids; AA/AdA: arachidonic acid/adrenic acid (AdA); AA/AdA-PEs: AA/AdA-phosphatidylethanolamine (PE); AA/AdA-PEs-OH: AA/AdA-PEs-alcohols; AA/AdA-PEs-OOH: AA/AdA-PEs-hydroperoxides; GPX4: Glutathione peroxidases 4; GSH: glutathione; GSSG: glutathione disulfide; LOXs: Lipoxygenases.