Figure 5.

Serum miRNAs responsive to idasanutlin treatment. (A) Differentially expressed miRNAs in serum of mice carrying orthotopic xenograft tumours of SH-SY5Y cells after 1 or 11 days of treatment with idasanutlin (30 mg/kg per day), temsirolimus (9 mg/kg/day) or vehicle control (P < 0.05 and FC > 2, Wald test, corrected for multiple testing using Benjamin–Hochberg). (B) Scaled log₂ expression levels of idasanutlin-responsive miRNAs in serum of mice treated with idasanutlin or vehicle control. Time points: −6 = 6 days before engraftment; 10 = 10 days after engraftment and 3 days before treatment; 15 = 15 days after engraftment and 1 day after start treatment; 25 = 25 days after engraftment and 11 days after start treatment.