Figure 6.

Serum and tumour expression levels of miR-34a-5p. (A) Serum expression levels of miR-34a-5p at different time points before and after treatment with idasanutlin (orange) or vehicle control (black). Serum was collected 6 days before engraftment (−6), 11 days after engraftment (11), one day after start of treatment (15) and 11 days after start of treatment (25). Solid lines represent mice carrying orthotopic xenograft tumours of SH-SY5Y cells; dashed lines represent non-engrafted, tumour-free mice. Error bars represent the standard error of the mean. (B) Boxplots of the expression levels of miR-34a-5p in tumours collected from mice treated for 11 days with idasanutlin or vehicle control.