Table 2.

Univariable and Multivariate Cox regression analysis for RFS.

	Univariable		Multivariate
	P	HR (95%CI)	P	HR (95%CI)
Model 1
Age (≤65 vs. >65)	0.962	1.010(0.550,1.870)	0.709	0.884(0.464,1.685)
Gender (male vs. female)	0.119	1.650(0.879,3.090)	0.341	1.478(0.662,3.299)
Histology subtype (SCC vs. ADC)	0.394	1.270(0.735,2.190)	0.944	0.976(0.493,1.933)
Pathologic stage (IIIA vs. IIB)	0.064	1.720(0.969,3.060)	0.134	1.562(0.871,2.799)
Pathologic stage (IIIB vs. IIB)	0.145	2.480(0.731,8.430)	0.167	2.423(0.691,8.496)
high TC-CD4+Tcon density	0.048	3.268(1.011,10.560)	0.053	3.455(0.986,12.107)
high IM-CD4+Treg density	0.035	1.916(1.048,3.497)	0.097	1.690(0.910,3.139)
high IM-CD8+Tdys density	0.012	3.876(1.355,11.050)	0.025	3.536(1.170,10.690)
Model 2
Age (≤65 vs. >65)	0.962	1.010(0.550,1.870)	0.891	1.045(0.558,1.956)
Gender (male vs. female)	0.119	1.650(0.879,3.090)	0.373	1.407(0.663,2.986)
Histology subtype (SCC vs. ADC)	0.394	1.270(0.735,2.190)	0.950	1.021(0.530,1.969)
Pathologic stage (IIIA vs. IIB)	0.064	1.720(0.969,3.060)	0.154	1.532(0.852,2.754)
Pathologic stage (IIIB vs. IIB)	0.145	2.480(0.731,8.430)	0.154	2.513(0.708,8.912)
high TC-CD4+Tcon proximity	0.044	1.783 (1.017 ,3.125)	0.416	1.284(0.703,2.347)
high IM-CD4+Treg proximity	0.007	3.021 (1.344 ,6.757)	0.012	2.884(1.258,6.615)

Boldface type indicates statistical significance on multivariate analysis. HR=hazard ratio, CI=confidence interval.