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. 2023 Jan 4;16:1011895. doi: 10.3389/fnins.2022.1011895

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Copyright © 2023 Tian, Cook and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The failure of existing registration algorithms in the cerebellum and olfactory bulb. (A,B) DWI; (C,D) NeuN image after registration; (E,F) overlaid DWI/NeuN (specimen 191209). The left hand column shows the result of Elastix (Klein et al., 2010) with rigid and b-spline registration and default settings. The registration errors in the olfactory bulb and brain stem are reduced but the errors in the dentate gyrus and cerebellum are significant (arrows in panel E). The right hand column shows the result of ANTs (Avants et al., 2008) with affine and SyN and default settings. There is a reasonable overlap in the dentate gyrus but significant mismatch in the cerebellum and olfactory bulb (arrows in panel F).