Figure 5.
Schematic diagram of the role of thymoquinone in enhancing the chemosensitivity of pancreatic cancer (TQ, thymoquinone; GEM, gemcitabine; Bcl, B cell leukemia/lymphoma; Akt, phosphorylated protein kinase B;Notch 1, neurogenic gene notch homolog protein 1; NICD, Notch intracellular domain; PTEN, phosphorase and tensin homolog; mTOR, mammalian target of rapamycin; PKM2, pyruvate kinase isozyme type M2; PARP, poly ADP-ribose polymerase; COX-2, cyclooxygenase 2; PGE2, prostaglandin E2).