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. 2023 Jan 4;13:1042835. doi: 10.3389/fimmu.2022.1042835

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Copyright © 2023 Sun, Li, Zhang, Zhao, Dong, Guo, Mo, Che, Ban, Li, Bai, Li, Hao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ST identifies hypoxia-related gene expression and distribution based on different hypoxic conditions in MDA-MB-231 engrafts. (A) Number of hypoxia-related genes in cluster 0, cluster 1, cluster 6, cluster 5, and cluster 10. (B) Distribution of hypoxia-related genes in different clusters. (C) Violin plots of HIF1A expression in cluster 0, cluster 1, cluster 6, cluster 5, and cluster 10. (D–G) Spatial feature plots of Human BINP3, CA9, P4HA1, and LDHA in sample (C) IHC for human BINP3, CA9, and P4HA1 in sample C and LDHA in sample B (scale bar, 1 mm). Violin plots of these genes’ expression in cluster 0, cluster 1, cluster 6, cluster 5, and cluster 10.