Extended Data Figure 5: Simulations suggest pulsatile inhibition of ppERK signaling can imitate the endogenous clock.

a, Simulation predictions for ppERK dynamics (plotted as kymographs in lab frame) for global inhibition experiments: Various drug concentrations (outer y-axis) and treatment/washout durations (outer x-axis) are simulated. Clock mutant (absent, b) and clock-intact (kinematic waves, c) simulations are also presented for comparison. Posterior is left.