Table 1.
Clinicopathologic characteristics of Müllerian adenosarcoma of the cervix in chronological order.
| Reference | Age | Parity | Presenting symptoms | Surgery | SO | Adjuvant therapy | Status(months) |
|---|---|---|---|---|---|---|---|
| Roth et al. (1976) (20) | 14 | 0 | Watery discharge | RH + partial vaginectomy+BSO+PLD | NM | Radiotherapy +chemotherapy | NED (42) |
| Ostor and Fortune (1980) (21) | 19 47 |
NM NM |
Vaginal discharge Metrorrhagia |
Polypectomy TAH+BSO |
No No |
No No |
AWD (132) NED (5) |
| Zaloudek et al. (1981) (18) | 15 | NM | Mass | Local excision | No | No | NED (48) |
| Gal et al. (1988) (22) | 14 | 0 | Mass | TAH+BSO | Yes | Chemotherapy+radiotherapy | DOD (18) |
| Gast et al. (1989) (15) | 15 | 0 | Mass | RH | No | No | NED (48) |
| Jones et al. (1995) (10) | 30 | NM | Mass | TAH + BSO | No | Chemotherapy | NED (27) |
| Ramos et al. (2002) (23) | 25 | 0 | Metrorrhagia | TAH+BSO | NM | No | NED (24) |
| Park et al. (2004) (24) | 37 | NM | Vaginal spotting | TAH+BSO+PLD | Yes | No | NED (9) |
| Manoharan et al. (2007) (2) | 26 28 43 |
2 0 1 |
Intermenstrual and postcoital bleeding Postcoital bleeding Postcoital bleeding |
Vaginal hysterectomy + PAND RH TAH |
No Yes No |
Radiotherapy Chemotherapy+radiotherapy No |
NED (36) NED (48) NED (NM) |
| Fleming et al. (2009) (25) | 10 | 0 | Vaginal bleeding | RH+BS+PLD+upper vaginectomy |
NM | No | NED (NM) |
| Bagga et al. (2010) (26) | 15 | 0 | Vaginal bleeding | TAH+BSO+PLB+partial omentectomy | No | No | NED (9) |
| Buyukkurt et al. (2010) (27) | 14 | 0 | Mass | Excisional biopsy | NM | No | NED (15) |
| Duggal et al. (2010) (28) | 15 | 0 | Foul smelling and menstrual bleeding | TAH+BSO+ omentectomy | Yes | Chemotherapy+radiotherapy | DOD (12) |
| Charfi et al. (2012) (29) | 26 | 0 | Mass | TAH | Yes | No | Unknown |
| Chin et al. (2013) (30) | 17 | 0 | Vaginal bleeding and introital mass | Cervical wedge resection | No | No | NED (204) |
| Sanamandra et al. (2014) (31) | 13 | 0 | Vaginal mass and vaginal bleeding | Tumor resection | NM | No | Unknown |
| Seagle et al. (2014) (32) | 54 47 |
NM NM |
Vaginal bleeding Vaginal bleeding |
RH+BSO+PLD+PAND Cervical biopsies |
Yes Yes |
Chemotherapy+radiotherapy Chemotherapy+radiotherapy |
NED (66) DOD (12) |
| Podduturi et al. (2016) (33) | 38 | 3 | Postcoital bleeding | NAC+ RH + BSO + PLD | Yes | No | NED (10) |
| Morales et al. (2016) (34) | 39 | NM | Pelvic pain + vaginal bleeding | RH+PLD | Yes | No (patient rejection) | AWD (21) |
| Shinnick et al. (2017) (35) | 14 | 0 | Mass | CKC | NM | No | Unknown |
| Kanayama et al. (2017) (36) | 28 | 0 | Mass | CKC | No | No | NED (32) |
| Koyuncuoğlu et al. (2017) (37) | 32 | 2 | Vaginal bleeding | TAH+BSO | Yes | Chemotherapy+radiotherapy | Unknown |
| Togami et al. (2018) (38) | 32 34 17 |
0 0 0 |
Vaginal bleeding Vaginal bleeding Vaginal bleeding and introital mass |
TAH+BS MRH+BSO+PLD+LAR Conization |
No No No |
No Pazopanib No |
NED (28) NED (13) NED (62) |
| Yuan et al. (2019) (39) | 19 32 |
0 0 |
NM NM |
Hysteroscopy+ TR Hysteroscopy+ TR |
Yes Yes |
Chemotherapy Chemotherapy |
NED (13) NED (10) |
AWD, alive with disease; BS, bilateral salpingectomy; BSO, bilateral salpingo-oophorectomy; CKC, cold knife conization; DOD, dead of disease; LAR, low anterior resection; MRH, modified radical hysterectomy; NAC, neoadjuvant chemotherapy; NED, no evidence of disease; NM, not mentioned; PAND, para-aortic node dissection; PLB, pelvic lymph node biopsy; PLD, pelvic lymph node dissection; RH, radical hysterectomy; TAH, total abdominal hysterectomy; TR, tumor resection.