Performance drift in the prediction model during the COVID pandemic. (A–D) Interrupted time series analyses of COVID pandemic impacts on (A) Percentage of high-risk encounters; (B) Absolute predicted 180-day mortality risk; (C) True-positive rate. Circles represent monthly observed averages across all medical oncology encounters. Solid lines reflect time trends in the prepandemic (January 2019–February 2020), early pandemic (March–May 2020), and later pandemic (June–December 2020) periods, with 95% confidence intervals surrounding each time trend in shaded grey. (D, E) Calibration plots for the pre-COVID (D) and post-COVID (E) periods, with a dashed line indicating the clinically relevant threshold used in practice. (F) Interrupted time series analysis of COVID pandemic impact on laboratory utilization. Circles represent monthly observed average percentage of encounters with prior associated laboratory utilization in the prior 180 days across all medical oncology encounters. Solid lines reflect time trends in the prepandemic (January 2019–February 2020), early pandemic (March–May 2020), and later pandemic (June–December 2020) periods, with 95% confidence intervals surrounding each time trend in shaded grey. (G) Prediction score by visit type in pre- versus later pandemic. The mean prediction score in the prepandemic period among the in-person visits was 0.13 (IQR: 0.02–0.17), while among telehealth visits, the mean prediction score was 0.03 (IQR: 0.01–0.03). In the later pandemic period, the mean prediction score among in-person visits was 0.11 (IQR: 0.01–0.12), while among telehealth visits, the mean prediction score was 0.12 (0.02–0.14). (H) Prediction score by laboratory utilization in pre- versus later pandemic. The mean prediction score in the prepandemic period among the encounters with laboratory utilization was 0.16 (IQR: 0.03–0.21), while among the encounters without any laboratory utilization, the mean prediction score was 0.015 (IQR: 0.013–0.014). In the later pandemic period, the mean prediction score among the encounters with labs was 0.14 (IQR: 0.02–0.18), among the encounters without labs was 0.015 (0.012–0.014).