Table 5.
Subgroup analysis between AST/ALT ratio and diabetes in participants with prediabetes.
| Characteristic | No of participants | Event (%) | HR (95%CI) | P-value | P for interaction |
|---|---|---|---|---|---|
| Age (years) | |||||
| < 45 | 4,359 | 255 (5.8) | 0.37 (0.25–0.56) | < 0.001 | 0.004 |
| 45–65 | 5,032 | 741 (14.7) | 0.43 (0.34–0.54) | < 0.001 | |
| >65 | 1,855 | 277 (14.9) | 0.56 (0.41–0.77) | < 0.001 | |
| BMI (Kg/m2) | |||||
| ≤ 25 | 5,982 | 463 (7.7) | 0.31 (0.24–0.41) | < 0.001 | 0.588 |
| >25 | 5,264 | 810 (15.4) | 0.44 (0.35–0.55) | < 0.001 | |
| TG (mmol/L) | |||||
| ≤ 1.70 | 6,973 | 608 (8.7) | 0.30 (0.23–0.38) | < 0.001 | 0.002 |
| >1.70 | 4,273 | 665 (15.6) | 0.60 (0.47–0.77) | < 0.001 | |
| HDL-C (mmol/L) | |||||
| ≤ 1.04 | 1,531 | 201 (13.1) | 0.32 (0.19–0.54) | < 0.001 | 0.181 |
| >1.04 | 9,715 | 1,072 (11) | 0.42 (0.35–0.50) | < 0.001 | |
| Family history of diabetes | |||||
| No | 10,978 | 1,226 (11.2) | 0.40 (0.34–0.48) | < 0.001 | 0.865 |
| Yes | 268 | 47 (17.5) | 0.54 (0.21–1.43) | 0.215 | |
Results are shown as hazard ratios (HRs) with 95% confidence intervals (CIs).
BMI, body mass index; TG, triglyceride; HDL-C, high-density lipid cholesterol.
Models are adjusted for age, gender, BMI, SBP, DBP, TG, TC, HDL-C, LDL-C, BUN, Scr, smoking status, drinking status, and family history of diabetes except for the subgroup variable itself.