Table 1.
Univariate analysis of clinical characteristics related to HE in patients with ICH
| Characteristic | Total (n = 317) |
HE (n =89) |
No HE (n =228) |
p-Value |
|---|---|---|---|---|
| Age(years) | 56(45,67.50) | 58(49,70) | 54(43,66) | 0.028* |
| Sex (male) | 230(72.6%) | 61(68.5%) | 169(74.1%) | 0.329 |
| Hypertension | 258(81.4%) | 76(85.4%) | 182(79.8%) | 0.335 |
| Diabetes mellitus | 26(8.2%) | 6(6.7%) | 20(8.8%) | 0.653 |
| Prior ischemic stroke | 10(3.2%) | 2(2.2%) | 8(3.5%) | 0.826 |
| Prior ICH | 11(3.5%) | 4(4.5%) | 7(3.1%) | 0.779 |
| Smoking | 98(30.9%) | 23(25.8%) | 75(32.9%) | 0.279 |
| Alcohol consumption | 83(26.2%) | 19(21.3%) | 64(28.1%) | 0.256 |
| Onset-to-first-CT time(hours) | 7(4,15) | 8(5,14.5) | 7(4,15) | 0.249 |
| SBP(mmHg) | 163 ± 27 | 162 ± 26 | 164 ± 27 | 0.664 |
| DBP(mmHg) | 96 ± 18 | 96 ± 16 | 97 ± 19 | 0.578 |
| GCS score on admission | - | - | - | < 0.001** |
| 13-15 | 114(36.0%) | 15(16.9%) | 99(43.4%) | - |
| 9-12 | 104(32.8%) | 29(32.6%) | 75(32.9%) | - |
| 3-8 | 99(31.2%) | 45(50.6%) | 54(23.7%) | - |
| NIHSS on admission | 12(9,14) | 12(10,14) | 10(9,13) | 0.019* |
| Infratentorial hematoma | 67(21.1%) | 20(22.5%) | 47(20.6%) | 0.760 |
| Hematoma size (ml) | 24.00(10.15,41.84) | 35.24(14.98,52.20) | 21.23(8.36,38.18) | <0.001** |
| Presence of IVH | 133(42.0%) | 42(47.2%) | 91(39.9%) | 0.256 |
| RBC, x1012 | 4.58 ± 0.72 | 4.44 ± 0.75 | 4.63 ± 0.70 | 0.031* |
| Hemoglobin(g/L) | 139 ± 20 | 135 ± 21 | 140 ± 19 | 0.061 |
| Neutrophil, x109 | 8.12(5.25,11.33) | 10.86(8.56,13.74) | 6.85(4.74,9.93) | <0.001** |
| Lymphocyte, x109 | 1.22(0.79,1.83) | 0.91(0.65,1.29) | 1.31(0.87,1.93) | <0.001** |
| Monocyte, x109 | 0.51(0.38,0.73) | 0.63(0.40,0.81) | 0.50(0.35,0.69) | 0.003* |
| Platelet, x109 | 185 ± 64 | 159 ± 60 | 195 ± 62 | <0.001** |
| NPR | 4.79(2.70,6.63) | 7.37(5.46,9.67) | 3.85(2.50,5.40) | <0.001** |
| PT (s) | 10.9(10.5,11.4) | 11.1(10.7,11.5) | 10.9(10.4,11.3) | 0.009* |
| APTT (s) | 26.1(24.4,27.6) | 25.4(24.2,27.6) | 26.3(24.6,27.6) | 0.224 |
| INR | 0.93(0.89,0.97) | 0.95(0.91,1.00) | 0.92(0.89,0.97) | 0.005* |
| Blood glucose (mmol/L) | 7.85(6.37,9.69) | 8.68(7.08,11.87) | 7.60(6.31,9.23) | <0.001** |
Values are n (%) and median (25,75%)
HE hematoma expansion, ICH intracerebral hemorrhage, SBP systolic blood pressure, DBP diastolic blood pressure, GCS Glasgow coma scale, NIHSS National Institutes of Health stroke scale, IVH intraventricular hemorrhage, RBC red blood cells, NPR neutrophil to platelet ratio, PT prothrombin time, APTT activated partial thromboplastin time, INR international normalized ratio
*p < 0.05. **p < 0.001