TABLE 4.

Histopathology in rabbit skin following i.d. challenge of infection-immune rabbits with B. burgdorferi

Cell type	Immunohistochemical staining at (h p.i.)a:
	2 (5/5)	12 (5/5)	24 (2/5)	36 (2/5)	48 (0/5)	72 (0/5)	96 (0/5)
B. burgdorferi	+b	+b	+, +/−b	−	−	−	−
B lymphocytes	−	−	−	−	−	−	−
T lymphocytes	−	−	−	−	−	−	−
CD11b+ cells	+c	++cd	++c	+/−d	+/−d	−	−

^aThe number of skin-culture-positive rabbits per total number of animals observed is indicated in parentheses. Observations made for four rabbits: −, none; +/−, few/some; +, moderate; ++, numerous. 

^bNo intact organisms were detected, but only B. burgdorferi antigen (Compare Fig. 4d to Fig. 3d). 

^cPMNs as determined by microscopic analysis of H&E-stained serial sections. 

^dMacrophages as determined by microscopic analysis of H&E-stained serial sections.