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. 2023 Jan 18;9:12. doi: 10.1038/s41420-023-01320-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Representative images of double-labeled with CD206 and F4/80 (M2 macrophage, white arrow) in lung revealed the increased (B) macrophages infiltration and decreased (C) M2 macrophage polarization after 5 mg/kg LPS exposure, which changes could be weakened with the inhibition of SPHK2. D mRNA levels for various inflammatory cytokine genes (TNF-α, iNOS, COX-2, IL-6, and IL-1β) among different groups. Data were presented as the means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001; N.S, not significant.