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. 2023 Jan 18;9:12. doi: 10.1038/s41420-023-01320-5

Fig. 8. Inhibition of SPHK2 with ABC294640 suppresses the acetylation levels of p53 as well as the activation of NLRP3 inflammasome in vivo.

Fig. 8

A Western blots of acetyl-p53 in the lung tissues from mice exposed to PBS or LPS, treating with DMSO or ABC294640. B Representative images of immunostaining for NLRP3 in the lung were shown (alveolar macrophages, black arrow). bar = 50 μm. C and D Western blots of NLRP3, Caspase-1 p20 and ASC in the lung tissues from mice. E The proposed model to illustrate the underlying mechanism that SPHK2/NLRP3 axis is implicated in the progression of ARDS. Data were presented as the means ± SEM from at least 3 independent experiments. *p < 0.05; **p < 0.01; ***p < 0.005.