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. Author manuscript; available in PMC: 2023 Aug 23.
Published in final edited form as: Circulation. 2022 Jul 18;146(8):e93–e118. doi: 10.1161/CIR.0000000000001077

Figure 1. Development of a PRS.

Figure 1.

A, Development of polygenic risk scores (PRSs). This typically involves attaining single nucleotide variant (SNV) effect sizes from a genome-wide association study (GWAS) and then adjusting these SNV effect sizes to account for linkage disequilibrium (LD). B, Training of the PRS. Typically, numerous PRSs are created per participant. Each PRS is then assessed through various association testing, and the most accurate PRS is collected. C, Validation of the PRS. The most accurate PRS is then validated in an independent cohort of participants.