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. 2023 Jan 11:NEJMc2213948. doi: 10.1056/NEJMc2213948

Figure 1. Neutralizing Antibody and T-Cell Responses after Monovalent or Bivalent mRNA Boosting.

Figure 1

Shown are the results of luciferase-based pseudovirus neutralization assays among participants who received booster doses of either monovalent (Panel A) or bivalent (Panel B) mRNA vaccines. Also shown are spike-specific CD8+ T-cell responses on intracellular cytokine staining assays among participants who received booster doses of either monovalent (Panel C) or bivalent (Panel D) mRNA vaccines, along with corresponding CD4+ T-cell responses with the two types of vaccines (Panels E and F). Responses were measured against the ancestral strain of SARS-CoV-2 (WA1/2020) and against omicron sublineages BA.1, BA.2, and BA.5. Red horizontal bars indicate median values, as shown above the data points. The values above the brackets are the numerical factor differences in the response against the BA.5 variant after boosting as compared with the response before boosting (upper brackets) and the factor differences after boosting for the response against the ancestral strain as compared with the response against the BA.5 sublineage (lower brackets).