. Author manuscript; available in PMC: 2023 Jan 18.

Published in final edited form as: Nat Med. 2018 Sep 17;24(10):1559–1567. doi: 10.1038/s41591-018-0177-5

Table 1.

Area Under the Curve (AUC) achieved by the network trained on mutations (with 95% CIs).

Mutations	Per tile AUC	Per slide AUC after aggregation by…
Mutations	Per tile AUC	… average predicted probability	… percentage of positively classified tiles
STK11	0.845 [0.838–0.852]	0.856 [0.709–0.964]	0.842 [0.683–0.967]
EGFR	0.754 [0.746–0.761]	0.826 [0.628–0.979]	0.782 [0.516–0.979]
SETBP1	0.785 [0.776–0.794]	0.775 [0.595–0.931]	0.752 [0.550–0.927]
TP53	0.674 [0.666–0.681]	0.760 [0.626–0.872]	0.754 [0.627–0.870]
FAT1	0.739 [0.732–0.746]	0.750 [0.512–0.940]	0.750 [0.491–0.946]
KRAS	0.814 [0.807–0.829]	0.733 [0.580–0.857]	0.716 [0.552–0.854]
KEAP1	0.684 [0.670–0.694]	0.675 [0.466–0.865]	0.659 [0.440–0.856]
LRP1B	0.640 [0.633–0.647]	0.656 [0.513–0.797]	0.657 [0.512–0.799]
FAT4	0.768 [0.760–0.775]	0.642 [0.470–0.799]	0.640 [0.440–0.856]
NF1	0.714 [0.704–0.723]	0.640 [0.419–0.845]	0.632 [0.405–0.845]

n = 62 slides from 59 patients