Table 3.

Common biomaterials used in enthesis engineering and brief summary of their advantages and disadvantages

	Acronym/chemical formula	Extended name	Advantages	Disadvantages	Ref.
Natural protein	SF	Silk fibroin	Biodegradability Mechanical properties Possibility to promote fiber growth	Poor cell recruitment properties	[69, 79–84]
	Col	Collagen	Biocompatibility Biodegradability	Poor mechanical properties	[85, 86]
Bioactive inorganic materials	Ca3(PO4)2	calcium phosphate	Osteoconductivity		[35, 71]
	CPS	Ca5(PO4)2SiO4	Biocompatibility Biodegradability		[71]
	HA	Hydroxyapatite	Bioactivity Biocompatibility Osteoconductivity	Slow biodegradation	[66, 87–89]
Synthetic materials	PLLA	Poly-L-lactic acid	Biodegradability Mechanical properties Easily processed		[72, 90]
	PLGA	Poly (lactide-co-glycolic acid)	Possibility of surface functionalization Biodegradability Mechanical properties Possibility to promote fiber growth		[85, 91]
	PGA	Polyglycolic acid	Possibility of surface functionalization Biodegradability Mechanical properties		[92]
	PCL	Polycaprolactone	Porosity Biodegradability Easily processed Biocompatibility Possibility to promote tissue formation and mineralization	Low bioactivity Quick biodegradation	[65, 67, 87, 89, 90, 93, 94]