TABLE 2.

G. biloba in the treatment of mild to moderate dementia.

	Study design (trial registration)	Patients	Interventions	Outcomes
G. biloba Schneider et al. (2005)	Randomized, placebo-controlled, double-blind, parallel-group, multicenter trial	Mild to moderate dementia (n = 513)	Patients received G. biloba 120 mg or 240 mg, or placebo for 26 weeks	A-2.05 ± 2.09 reduction in 11-Point Box Scale tinnitus score vs. placebo -.21 ± 1.69
G. biloba EGb 761 Herrschaft et al. (2012)	Double-blind, placebo-controlled RCT	Mild to moderate dementia with neuropsychiatric features (n = 410)	Patients received a 240 mg once-daily formulation of G. biloba extract EGb 761 or placebo for 24 weeks	No difference in 11-Point Box Scale tinnitus score between patients receiving G. biloba extract EGb 761 and those receiving placebo
G. bilobaEGb 761 (Napryeyenko and Borzenko, 2007)		Mild to moderate dementia with neuropsychiatric features (n = 400)	Patients received G. biloba EGb 761 or placebo for 22 weeks	A-2.11 ± 1.74 reduction in 11-Point Box Scale tinnitus score vs. placebo -.15 ± 1.01
G. biloba EGb 761 Ihl et al. (2011)		Mild to moderate dementia with neuropsychiatric features (n = 410)	Patients received 240 mg of G. biloba EGb 761 or placebo once daily for 24 weeks	A-1.11 ± 1.21 reduction in 11-Point Box Scale tinnitus score vs. placebo -.14 ± 1.92