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. 2022 Dec 5;14(3):658–667. doi: 10.1039/d2sc05147h

Fig. 1. Main metabolic reactions that determine the turnover of inositol pyrophosphates in mammalian cells. Three isoforms of IP6Ks phosphorylate the 5-position of InsP6 and two isoforms of PPIP5Ks phosphorylate the 1-position with a preference for 5-PP-InsP5 over InsP6. The question mark indicates that an unknown pathway is responsible for the synthesis of the 4/6-PP-InsP5 and 2-PP-InsP5 identified in the current study (inside dotted box, note that 4/6-PP-InsP5 are enantiomers). PPIP5Ks also harbour a phosphatase domain catalyzing dephosphorylation 1,5-(PP)2-InsP4. DIPPs are specialized phosphatases that degrade the phosphoric anhydrides in PP-InsPs.

Fig. 1