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. 2023 Jan 4;13:1089667. doi: 10.3389/fphar.2022.1089667

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Copyright © 2023 Abu-Serie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of DF(II) complexes on the gene expression of apoptotic, oncogenes, and stemness genes. Relative fold change in the gene expression of apoptotic genes (BAX and p21), key oncogenes (cyclin D, telomerase reverse transcriptase (TERT), vascular endothelial growth factor (VEGF), matrix metalloprotease (MMP) 9-mediated metastasis), and stemness (ATP Binding Cassette Subfamily G Member 2 (ABCG2), CD90, NOTCH1, WNT1, Sox9, 4-OCT, and Nanog) in tumor tissues, including (A) liver and (B) lung. Data are shown as mean ± SEM. LC-DF(II) NPs group was compared to the untreated LC and LC-DF(II) groups, considering statistically significant at p ≤ 0.05*, ≤0.005**, and ≤0.001***.