TABLE 2.
Univariate and multivariate Cox proportional hazards analyses of PIF1 expression and OS for patients with ccRCC.
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| T stage | 539 | ||||
| T1&T2 | 349 | Reference | |||
| T3&T4 | 190 | 3.228 (2.382-4.374) | <0.001 | 1.259 (0.552-2.870) | 0.584 |
| N stage | 257 | ||||
| N0 | 241 | Reference | |||
| N1 | 16 | 3.453 (1.832-6.508) | <0.001 | 1.435 (0.715-2.880) | 0.310 |
| M stage | 506 | ||||
| M0 | 428 | Reference | |||
| M1 | 78 | 4.389 (3.212-5.999) | <0.001 | 2.342 (1.368-4.010) | 0.002 |
| Pathologic stage | 536 | ||||
| Stage I&Stage II | 331 | Reference | |||
| Stage III&Stage IV | 205 | 3.946 (2.872-5.423) | <0.001 | 1.572 (0.612-4.038) | 0.347 |
| Histologic grade | 531 | ||||
| G1&G2 | 249 | Reference | |||
| G3&G4 | 282 | 2.702 (1.918-3.807) | <0.001 | 1.709 (1.036-2.821) | 0.036 |
| Laterality | 538 | ||||
| Left | 252 | Reference | |||
| Right | 286 | 0.706 (0.523-0.952) | 0.023 | 1.094 (0.710-1.687) | 0.683 |
| PIF1 | 539 | ||||
| Low | 269 | Reference | |||
| High | 270 | 2.061 (1.511-2.812) | <0.001 | 2.046 (1.290-3.246) | 0.002 |
ccRCC, Clear Cell Renal Cell Carcinoma; OS, overall survival.