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. 2023 Jan 18:1–9. Online ahead of print. doi: 10.1007/s11010-023-04658-7

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Fig. 1 — Pathway of sphingosine-1-phosphate (S1P). Sphingosine is converted by sphingosine kinase (Sphk1/2) to S1P, which leads to a cellular response through S1P receptors (S1PR1-5). Sphingosine lyase (S1PL) metabolises S1P to inactive metabolites