TABLE 1.
Second Pediatric Acute Lung Injury Consensus Conference Subgroups and Related Key Questions
| Second PALICC Subgroups | Topic | Key Question |
|---|---|---|
| Section 1 | Definition, incidence, and epidemiology | How should PARDS be defined, and what are the variables that best characterize the global burden of PARDS? |
| Section 2 | Pathobiology, severity, and risk stratification | What are pediatric-specific elements of the pathobiology of PARDS, and what is the association between pathobiology and severity, and risk stratification in PARDS? |
| Section 3 | Invasive ventilatory support | What is the effectiveness and comparative effectiveness of different ventilation strategies for children with PARDS? |
| Section 4 | Ancillary pulmonary-specific treatments | What is the effectiveness and comparative effectiveness of pulmonary-specific ancillary treatments in children with PARDS? |
| Section 5 | Nonpulmonary treatments | What is the effectiveness and comparative effectiveness of nonpulmonary treatments in children with PARDS? |
| Section 6 | Monitoring | What is the role of different monitoring strategies in patients with PARDS? |
| Section 7 | Noninvasive respiratory support | What is the effectiveness of noninvasive ventilatory support in PARDS? |
| Section 8 | Extracorporeal support | What is the effectiveness of extracorporeal membrane oxygenation in children with PARDS? |
| Section 9 | Morbidity and long-term outcomes | What are the morbidity and long-term outcomes in PARDS? |
| Section 10 | Clinical informatics and data science | How can informatics, data science, and computerized decision support tools improve the diagnosis and management of PARDS? |
| Section 11 | Implementation in RLS | How should the recommendations for the diagnosis and management of PARDS be adapted to the context of RLS? |
PALICC = Pediatric Acute Lung Injury Consensus Conference, PARDS = pediatric acute respiratory distress syndrome, RLS = resource-limited settings.