TABLE 2.
Baseline Characteristics Among Included Studies
| Study, Year | Asfar et al (27) | Lamontagne et al (28) | Lamontagne et al (4) | |||
|---|---|---|---|---|---|---|
| Randomized Group | Lower MAP Target | Higher MAP Target | Lower MAP Target | Higher MAP Target | Lower MAP Target | Higher MAP Target |
| n | 388 | 388 | 60 | 58 | 1,283 | 1,300 |
| Baseline characteristics | ||||||
| Age, yr | 65 (15) | 65 (13) | 66 (13) | 63 (13) | 75.3 (6.6) | 75.2 (6.9) |
| Sex, male, n (%) | 250 (64.4) | 267 (68.8) | 31 (51.7) | 33 (56.9) | 696 (57.2) | 692 (55.9) |
| Duration of vasopressor at randomization (min) | 216 (126) | 210 (132) | 540 (180–960) | 660 (300–1,020) | 186 (102–277) (n = 1,247) | 186 (104–284) (n = 1,262) |
| Comorbidities | ||||||
| Hypertension, n (%) | 173 (44.6) | 167 (43.0) | 34 (56.7) | 19 (32.8) | 590 (46.0) | 597 (46.0) (n = 1,299) |
| Left ventricular failure, n (%) | 53 (13.7) | 59 (15.2) | 4 (6.7) | 6 (10.3) | 143 (11.1) | 143 (11.0) (n = 1,298) |
| Cause(s) of vasodilatory hypotension, n (%) | Sepsis, 388 (100) | Sepsis, 388 (100) | Sepsis, 46 (76.7) | 37 (63.8) | Sepsis, 953 (78.4) | 964 (77.8) |
| Pancreatitis, 3 (5.0) | 0 | Not sepsis, 263 (21.6) | 275 (22.2) | |||
| Overdose, 1 (1.7) | 0 | (n = 1,216) | (n = 1,239) | |||
| Pulmonary embolism, 2 (3.3) | 1 (1.7) | |||||
| Burns, 1 (1.7) | 2 (3.4) | |||||
| Other, 7 (11.7)a | 18 (31.0)b | |||||
| Illness severity | ||||||
| Sequential Organ Failure Assessment | 10.8 (3.1) | 10.7 (3.1) | — | — | — | — |
| Simplified Acute Physiology Score II score | 57.2 (16.2) | 56.1 (15.5) | — | — | — | — |
| Acute Physiology and Chronic Health Evaluation II | — | — | 24 (8) | 25 (6) | 20.9 (6.5) (n = 1,213) | 20.6 (6.1) (n = 1,239) |
MAP = mean arterial pressure.
a
Includes two patients in whom the admission diagnosis was unrelated to hypotension.
b
Includes 10 patients in whom the admission diagnosis was unrelated to hypotension.
Values are mean (sd) or median (interquartile range) as appropriate, unless otherwise specified. Dashes indicate data not reported.