Table 2.
Downregulated genes in cocultured Fusobacterium nucleatum.
| Gene no. or ID | Annotation | log2(co/mono*) |
|---|---|---|
| CS401_RS04350 | DUF2194 domain-containing protein | −6.008 |
| purE | 5-(carboxyamino)imidazole ribonucleotide mutase | −4.496 |
| CS401_RS07440 | Queuosine precursor transporter | −4.47 |
| CS401_RS07445 | Radical SAM protein | −4.342 |
| CS401_RS04345 | Hypothetical protein | −4.221 |
| CS401_RS08470 | CoA-disulfide reductase | −4.058 |
| CS401_RS08465 | Helix-turn-helix transcriptional regulator | −3.871 |
| CS401_RS07475 | Sodium-dependent transporter | −3.767 |
| purF | Amidophosphoribosyltransferase | −3.713 |
| CS401_RS02225 | Phosphoribosylaminoimidazole-succinocarboxamide synthase | −3.712 |
| CS401_RS04965 | Hypothetical protein | −3.641 |
| bioA | Adenosylmethionine—8-amino-7-oxononanoate transaminase | −3.633 |
| purM | Phosphoribosylfomylglycinamidine cyclo-ligase | −3.557 |
| CS401_RS02215 | Hypothetical protein | −3.548 |
| pelF | GT4 family glucosyltransferase PelF | −3.501 |
| CS401_RS02235 | Phosphoribosylformylglycinamidine synthetase | −3.469 |
| CS401_RS04330 | Hypothelical protein | −3.463 |
| CS401_RS02205 | Phosphoribosylglycinamide formyltransferase | −3.454 |
| pelG | Exopolysaccharide Pel transporter PelG | −3.327 |
| CS401_RS04355 | Hypothetical protein | −3.307 |
| CS401_RS10000 | Aspartate carbamoyltransferase catalytic subunit | −3.302 |
| megL | Methionine gamma-lyase | −3.219 |
| CS401_RS06670 | A24 family peptidase | −3.17 |
| CS401_RS10010 | Dihydroorotase | −3.13 |
| CS401_RS09550 | Na+/H+ antiporter NhaC family protein | −3.086 |
| CS401_RS02200 | Class I SAM-dependent methyltransferase | −3.044 |
| CS401_RS04325 | Endo alpha-1,4 polygalactosaminidase | −2.998 |
| CS401_RS10045 | Hypothetical protein | −2.939 |
| CS401_RS07480 | Tyrosine phenol-lyase | −2.834 |
| CS401_RS10015 | Glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit | −2.806 |
| carA | Orotidine-5’-phosphate decarboxylase | −2.788 |
| purH | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | −2.757 |
| CS401_RS08865 | ABC transporter ATP-binding protein/permease | −2.741 |
| CS401_RS05375 | 6.7-dimethyl-8-ribityllumazine synthase | −2.736 |
| CS401_RS02575 | Alpha/beta hydrolase | −2.722 |
| CS401_RS08540 | Hypothetical protein | −2.708 |
| CS401_RS00210 | TonB-dependent receptor | −2.704 |
| ribD | Bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase | −2.6 |
| CS401_RS10025 | Dihydroorotate dehydrogenase electron transfer subunit | −2.506 |
| CS401_RS10020 | Carbamoyl-phosphate synthase large subunit | −2.46 |
| CS401_RS08600 | 3-aminobutyl-CoA ammonia lyase | −2.419 |
| CS401_RS09220 | Transcription antiterminator | −2.411 |
| CS401_RS10030 | Dihydroorotate dehydrogenase | −2.377 |
| CS401_RS09160 | Cytochrome c biogenesis protein CcdA | −2.368 |
| CS401_RS02190 | Phosphoribosylamine – glucine ligase | −2.322 |
| pflA | Pyrvate formate-lyase-activating protein | −2.276 |
| CS401_RS05390 | Riboflavin synthase | −2.249 |
| cbpF | CEACAM-binding trimeric autotransporter adhesin CbpF | −2.244 |
| pflB | Formate C-acetyltransferase | −2.235 |
| CS401_RS06640 | Hypothelical | −2.234 |
| nifJ | Pyruvate:ferredoxin (flavodoxin) oxidoreductase | −2.21 |
| CS401_RS09995 | Bifunctional pyr operon transcriptional regulator/Uracil phosphoribosyltransferase PyrR | −2.198 |
| CS401_RS02270 | M42 family metallopeptidase | −2.196 |
| pyrE | Orotate phosphoribosyltransferase | −2.15 |
| CS401_RS07595 | HPr family phosphocarrier protein | −2.121 |
| CS401_RS09080 | RNA-binding protein | −2.095 |
| CS401_RS02570 | Hypothetical protein | −2.058 |
| CS401_RS08860 | ABC transporter ATP-binding protein/permease | −2.011 |
| CS401_RS05160 | Hypothetical protein | −1.994 |
| CS401_RS07575 | Hypothetical protein | −1.954 |
| CS401_RS08855 | Flavodoxin | −1.938 |
| CS401_RS06490 | Flavodoxin | −1.898 |
| CS401_RS03225 | Acetyl-CoA hydrolase/transferase family protein | −1.844 |
| CS401_RS08625 | Hypothetical protein | −1.841 |
| CS401_RS06480 | NrdH-redoxin | −1.838 |
| CS401_RS09340 | AAA family ATPase | −1.812 |
| CS401_RS06480 | Ribonucleoside-diphosphate reductase subunit alpha | −1.802 |
| CS401_RS03235 | Mechanosensitive ion channel | −1.781 |
| CS401_RS08655 | 3-keto-5-aminohexanoate cleavage protein | −1.735 |
| CS401_RS01275 | HAD-IB family hydrolase | −1.723 |
| CS401_RS07720 | Hypothetical protein | −1.719 |
| CS401_RS02565 | WGR domain-containing protein | −1.702 |
| CS401_RS04775 | DUF1871 family protein | −1.692 |
| CS401_RS0675 | Ribonucleotide-diphosphate reductase subunit beta | −1.677 |
| CS401_RS07725 | Hypothetical protein | −1.637 |
| CS401_RS08570 | 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis protein | −1.635 |
| CS401_RS01055 | DUF1456 family protein | −1.615 |
| CS401_RS09170 | thiol:disulfide interchange protein | −1.579 |
| CS401_RS06365 | Hypothetical protein | −1.573 |
| CS401_RS05800 | ATP-dependent DNA helicase RecG | −1.549 |
| CS401_RS08910 | Osmolarity sensor protein EnvZ | −1.547 |
| CS401_RS00170 | glutamate dehydrogenase | −1.535 |
*co/mono: coculture/monoculture.