Table 7.
Gene mutations in Moxifloxacin-resistant isolates.
| Isolates | Gene | Nucleotide (codon) | Mutation | Amino acid change | N of mutants |
|---|---|---|---|---|---|
| M. kansasii | gyrA | 238,239 (80) | ACG→GGG | Threonine →Glycine | 1 |
| 247,249 (83) | AAC→CAA | Asparagine →Glutamine | 2 | ||
| 257,258 (86) | CCG→CGA | Proline →Arginine | 1 | ||
| 260,261 (87) | CAC→CGG | Histidine → Arginine | 4 | ||
| gyrB | 2449,2450 (817) | GCG→TGG | Alanine →Tryptophan | 4 | |
| 2452 (818) | CTC→TTC | Leucine -→Phenylalanine | 2 | ||
| 602,603 (201) | AAC→ACG | Asparagine → Threonine | 2 | ||
| 950 (317) | GAA→CGA | Glutamic acid → Glycine | 3 | ||
| 1332 (444) | GAC→GAG | Aspartic acid→Glutamic acid | 2 | ||
| 1339 (447) | TCG→ACG | Serine → Theronine | 2 | ||
| 1390,1392 (464) | GGC→TGT | Glycine → Cysteine | 1 | ||
| 1406 (469) | AGC→AAC | Serine → Asparagine | 2 | ||
| 1594 (532) | GAC→AAC | Aspartic acid → Asparagine | 2 |