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. 2023 Jan 11;38(1):2152810. doi: 10.1080/14756366.2022.2152810

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Scheme 3. — Synthesis of 2-pyridone/2-thiopyridine/2-aminopyridine – quinolone hybrids. (a) CH₃COOH, reflux; (b) 3-hydroxyacetophenone / ammonium acetate/ CNCH₂COOC₂H₅/ ethanol, reflux; (c) 3-hydroxyacetophenone /ammonium acetate / CNCH₂CSNH₂/ ethanol, reflux; (d) 3-hydroxyacetophenone /ammonium acetate / CNCH₂CN/ ethanol, reflux.