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IC50 values of Topoisomerase II inhibition and DNA intercalation of the tested compounds.
| Compound | IC50a [µM] |
|
|---|---|---|
| Topoisomerase II | DNA intercalation DNA/methyl green |
|
| 6 | 6.9 | 19.6 |
| 7 | 9.1 | 29.6 |
| 13a | 8.3 | 22.6 |
| Doxorubicin | 9.65 | 31.27 |
a“Values are expressed as average of three independent replicates”. “IC50 values were calculated using sigmoidal non-linear regression curve fit of percentage inhibition against five concentrations of each compound”.
