Table 6.

Identified significant gene ontologies associated with the comorbidities.

Database	GO ID	Gene ontology	P value	Genes in the ontology	Associated comorbidity
GO biological process	GO: 0006954	Inflammatory response	3.18E − 06	SERPINA3; CXCL10; CXCL9; CXCL8; ADORA2A; CCL20; IL1B; ABCF1	Hypertension
GO biological process	GO: 0032496	Response to lipopolysaccharide	2.89E − 06	CXCL10; CXCL9; CXCL8; IL1B; SERPINE1; ANKRD1; S100A7	Hypertension
GO biological process	GO: 0019221	Cytokine-mediated signaling pathway	1.04E − 04	CXCL8; IFI27; IL23A; HLA-B; HLA-DRA; TRIM26; LMNB1; PSMB9	Diabetes
GO biological process	GO: 0043312	Neutrophil degranulation	2.80E − 02	HLA-B; MCEMP1; MMP8; OSCAR	Diabetes
GO biological process	GO: 0002283	Neutrophil activation involved in immune response	2.87E − 02	HLA-B; MCEMP1; MMP8; OSCAR	Diabetes
GO biological process	GO: 0030198	Extracellular matrix organization	3.59E − 04	MMP7; ITGB2; LCP1; MMP8; NPNT; MMP9	Obesity
GO biological process	GO: 0043062	Extracellular structure organization	5.93E − 04	MMP7; ITGB2; MMP8; NPNT; MMP9	Obesity
GO cellular component	GO: 0005887	Integral component of plasma membrane	8.31E − 03	KIRREL3; CHRNA1; VIPR1; KIRREL2; GCGR; SEMA3G; SLC1A3; PTPRH; MERTK; AGER; SLC8A2; AQP1; TGFBR3; CDH2; P2RY1; SYNDIG1; CD36; RHCG; IL6R	Lung cancer
GO cellular component	GO: 0062023	Collagen-containing extracellular matrix	3.82E − 06	VWF; ATRNL1; COL11A2; BGN; NPNT; L1CAM; SOD3; MFAP4; CDH2; COL5A3; SMOC1; ANGPTL2; HMCN1	Lung cancer
GO biological process	GO: 0050808	Synapse organization	3.65E − 06	KIRREL3; CHRNA1; CDH2; DSCAM; SPOCK2; L1CAM; SHANK3; SLC8A2	Lung cancer